Viral Infections
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Increasing Incidence of Stage IV Cervical Cancer
The incidence of stage IV cervical cancer in the United States between 2001 and 2018 increased. Rates were highest among Black women, but the annual rate of increase was highest among white women in the South age 40-44 years.
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Evidence of Clinical Efficacy of Bebtelovimab in COVID-19
A retrospective study found that bebtelovimab has efficacy similar to that of nirmatrelvir/ritonavir (Paxlovid) in the treatment of high-risk outpatients with recent onset of COVID-19 who have mild to moderate symptoms.
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COVID-19: Beware Remdesivir Resistance
Hogan and colleagues reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in ribonucleic acid (RNA)-dependent RNA polymerase after remdesivir treatment.
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Outbreak of a Potentially More Lethal Ebola Virus
A new outbreak of a more lethal Ebola virus is occurring in Uganda with concern about its exportation.
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Can Maternal COVID-19 Vaccination Protect Newborns?
In this case control study, 537 case infants younger than 6 months of age who were admitted to the hospital with COVID-19 were compared to 512 control infants who were hospitalized for other reasons; 16% of the case infants and 29% of the control infants had been born to mothers who had been fully vaccinated against COVID-19 during the pregnancy. The effectiveness of maternal vaccination against infant hospitalization for COVID-19 was 52% overall, 80% during the Delta variant period, and 38% during the Omicron variant period. Effectiveness increased when the vaccine was received after 20 weeks of pregnancy.
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Antibiotic Resistance: We Were Doing Great and then COVID Happened
After improvement, antimicrobial resistance in the United States significantly increased.
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Bivalent COVID-19 Vaccine (Booster Dose)
The FDA has amended the emergency use authorizations of two leading COVID-19 vaccines. Now, these new bivalent formulations can be used as a single booster dose (after primary or booster vaccination).
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Frontline Providers Must Consider Dual Threats of AFM Resurgence, Polio Return
The CDC is advising frontline providers of a potential surge in cases of acute flaccid myelitis (AFM), a rare, polio-like complication of certain enteroviruses. Concurrently, there are concerns about the re-emergence of poliomyelitis.
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How Did Paralytic Polio Re-Emerge in the U.S.?
Most outbreaks globally are attributed to vaccine-derived polio, or type 2. Cases of the type 2 form of polio stem from the large-scale, global use of the oral polio vaccine, a solution that contains a live (but weakened) virus.
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Kindergarten Vaccine Rates: Post-COVID
The COVID-19 pandemic caused disruption in healthcare delivery for everyone. Schools continue to struggle to meet the Healthy People 2030 Nationwide target of ≥ 95% coverage for measles, mumps, rubella (MMR) vaccination in kindergarteners, and COVID-19 did not help. Remarkably, the nationwide vaccine rate for children entering kindergarten in the 2020-2021 school year was decreased by only 1% for all vaccines compared with the previous year.