Viral Infections
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Viruses, Newborns, and Liver Failure
Neonatal liver failure due to herpesvirus infection is rare but can be severe. Herpes simplex virus 1 (HSV-1) is a more likely cause than HSV-2. Only about two-thirds of affected patients survive, despite recommended treatment with parenteral acyclovir.
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Metformin Reduces SARS-CoV-2 Viral Load in Outpatients with COVID-19
A randomized, placebo-controlled clinical trial of outpatients with COVID-19 found that metformin reduced SARS-CoV-2 viral load 3.6-fold compared to placebo, while ivermectin and fluvoxamine showed no benefit.
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The Rise of Oropouche Virus
Oropouche virus is an arthropod-borne virus that has been primarily endemic to the Amazon region. The incidence of Oropouche virus disease has significantly increased over the past few years, and recent outbreaks have been reported in areas without previous endemic transmission and have led to fatalities and vertical transmission resulting in adverse pregnancy outcomes.
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Enlargement of Choroid Plexus in Subacute COVID-19 Patients
The choroid plexus is a network of capillaries whose main role involves facilitating cerebrospinal fluid production and the exchange of nutrients and waste products between the central nervous system and the bloodstream. Immune cells are present near the choroid plexus. Enlargement of the choroid plexus has been noted in patients with multiple sclerosis.
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Out of Africa Again? A New Version of Mpox
A novel mpox clade has emerged in Africa and has the potential for a global epidemic.
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Dengue Is Surging, Including in the Americas
Dengue is surging, and cases have been acquired in the United States, including in Puerto Rico and Florida.
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Being Mindful of COVID’s Effects on Cognitive Decline
A large observational study finds objective evidence of lingering cognitive deficits associated with past COVID-19 infection, particularly in patients infected early in the pandemic, those hospitalized, or those with prolonged illness duration.
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Respiratory Syncytial Virus or Influenza in Older Patients: Which Is Worse?
In individuals 75 years of age or older, respiratory syncytial virus infection was associated with more severe illness than was influenza virus infection.
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Avian Influenza A(H5N1) — From Birds to Cows to Human Infection
The spread of influenza H5N1 in dairy cows with documentation of a human infection raises pandemic concern.
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Respiratory Syncytial Virus or Influenza in Older Patients: Which Is Worse?
In individuals 75 years of age or older, respiratory syncytial virus infection was associated with more severe illness than was influenza virus infection.