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In this issue: Side effects of finasteride; new ruling on pharmaceutical companies paying generic manufacturers; and FDA actions.
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Using a statewide administrative database and other sources, Gershengorn and colleagues examined data on all adult patients with a primary diagnosis of diabetic ketoacidosis (DKA) who were admitted to hospitals in the state of New York from 2005-2007.
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Rachmale and colleagues retrospectively identified 210 patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) undergoing mechanical ventilation for longer than 48 hours.
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Family members of patients recovering from critical illness may experience psychological problems, including anxiety, depression, and post-traumatic stress disorder (PTSD). Jones and colleagues reasoned that provision of an ICU diary, written in everyday language by ICU staff, would be beneficial to family members by providing an explanation of daily events and opportunity for expression of feelings and contribution to the plan of care.
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The cuff-leak test (CLT) was performed prospectively in this study using the volume technique whereby the difference between inspired and expired tidal volume before and after cuff deflation is used to detect the presence of laryngeal edema and the likelihood of developing post-extubation stridor.
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Doernberg and colleagues sought to determine whether receipt of doxycycline was associated with protection from development of Clostridium difficile infection (CDI) in hospitalized patients being treated with ceftriaxone, a known high-risk antibiotic for CDI.
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In this issue: Dementia and benzodiazepines; effectiveness of omega-3 fatty acid and Ginkgo biloba supplements; and FDA actions.
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As more patients are surviving critical illness, there is documentation of serious cognitive, physical, and psychiatric consequences arising from lengthy ICU stays in these patients.
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The authors note a paucity of literature on early (0-48 hours of ventilation and ICU admission) sedation practices and their impact on outcomes; thus they performed this multicenter prospective cohort study with the hypothesis that early sedation is associated with delirium, time to extubation, and hospital and 180-day mortality.