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Evaluation of non-Parkinsonian carriers of the LRRK2 mutation associated with Parkinson's disease supports a model of pre-motor symptomatology, including impaired color discrimination and constipation, that could be related to pathology developing prior to that in the substantia nigra.
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Based on data from the Nurses' Health Study II, the authors report that higher maternal intake of vitamin D during pregnancy may be associated with a lower risk of multiple sclerosis in their children.
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ACEI/ARB therapy for AS; safety alert issued for dronedarone; statins and cancer risk; nesiritide and heart failure; and FDA actions.
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A new autosomal-dominant genetic disorder is described that has similarities to sporadic motor neuron disease.
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The incidence of stroke associated with pregnancy, especially cerebral venous sinus thrombosis, is increasing, with hypertension as a major culprit. Hypertension as a complication of pregnancy increases a woman's risk of stroke in the future.
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Gabapentin enacarbil is effective for sleep disturbance in moderate-to-severe primary restless legs syndrome, but frequently causes sleepiness and dizzinesss.
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Symptoms of muscle pain and discomfort are common with statin use, but weakness and creatine kinase elevation are unusual.
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Pulmonary contusions are a frequent complication of chest trauma and may have serious morbidity and mortality associated with them. Early recognition, aggressive management, and a targeted diagnostic approach may optimize outcomes for these patients. The authors present a concise, comprehensive review of the current status of identification and management of pulmonary contusions.
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Abdominal pain with vomiting is a common presenting complaint to the emergency department (ED) in infants. In the majority of cases, the patient's symptoms come from a benign cause such as gastroenteritis. However, it remains essential for the emergency physician (EP) to thoroughly understand the differential diagnosis of abdominal pain and vomiting in infants, particularly identifying those causes requiring surgical intervention.