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Evinacumab-dgnb Injection (Evkeeza)
Evinacumab-dgnb should be prescribed as an adjunct to other low-density lipoprotein cholesterol-lowering therapy to treat patients age 12 years and older with homozygous familial hypercholesterolemia.
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Prednisone vs. Placebo in Short-Term Prevention of Episodic Cluster Headaches
Prednisone, given at 100 mg for five days and then tapering by 20 mg every three days, is a safe and effective short-term prevention for episodic cluster headaches while waiting for longer-acting preventive agents to be initiated.
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Early Convalescent Plasma to Treat COVID-19 in Elderly Patients with Mild Symptoms
Administering convalescent plasma obtained from survivors of COVID-19 within 72 hours of onset of mild symptoms in elderly patients with the virus was associated with a significant reduction in the risk of development of severe respiratory disease.
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COVID-19 Patients Can Be Managed Safely with Noninvasive Respiratory Techniques
In adult patients hospitalized with COVID-19 for one month, using a noninvasive respiratory protocol that encouraged high-flow nasal cannula, noninvasive mechanical ventilation, and self-proning did not result in any significant increase in mortality.
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Healthcare Workers with COVID-19 Antibodies: Strong Protection Against Reinfection
A study of healthcare workers demonstrated the presence of antibody to SARS-CoV-2 spike protein or to nucleocapsid provides strong protection against infection for up to six months.
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THC-Related Neuropsychiatric Symptoms in Older Adults
Using cannabis-based medicine often exposes patients to delta-9-tetrahydrocannabinol (THC), which is associated with psychotic symptoms. THC also can cause lightheadedness, dizziness, and thinking or perception disorder in older adults.
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Low BNP Levels in Up to 16% of Heart Failure Patients
In patients with clinical heart failure and low B-type natriuretic peptide levels, the authors found these patients usually are young and obese, with higher ejection fraction and better renal function.
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PFO Closure for Resistant Migraines: Finding an Elusive Link
A meta-analysis of two randomized trials of patent foramen ovale closure in resistant migraine showed a significant benefit in three of four clinical endpoints.
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Intracranial Plaque Rupture and Stroke
An MRI study of cerebral circulation in patients with embolic stroke of undetermined etiology showed evidence of atherosclerotic plaque in most patients, supporting the theory that unstable intracranial artery plaques play an etiologic role in embolic stroke.
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Can Left Ventricular Strain Detect Early Cardiac Toxicity of Cancer Chemotherapy?
Using left ventricular peak systolic global longitudinal strain vs. left ventricular ejection fraction to survey patients undergoing potentially cardiotoxic chemotherapy with at least one other risk factor for heart failure showed no difference in the primary endpoint of the difference in ejection fraction between the two groups at one year.