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A New Treatment for Refractory Hyperlipidemia
In patients with familial hypercholesterolemia who are not at target LDL cholesterol levels on maximum-tolerated doses of statins and PCSK9 inhibitors, evinacumab, which inhibits angiopoietin-like 3, reduces LDL by more than 50% at the highest doses with few side effects requiring drug discontinuation vs. placebo.
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Expanding Uses for Direct Oral Anticoagulants: Bioprosthetic Heart Valves?
A randomized, controlled trial of rivaroxaban vs. warfarin in patients with atrial fibrillation and a bioprosthetic valve revealed rivaroxaban is noninferior to warfarin for the prevention of major cardiovascular events and the avoidance of major bleeding events over 12 months.
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Time is of the Essence with Colchicine Treatment of Myocardial Infarction
An analysis of the COLCOT study of colchicine administration after myocardial infarction (MI) showed the benefit of this therapy for preventing subsequent cardiovascular events was greatest when therapy was initiated within three days after MI onset.
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Left Ventricular Size, Function Predictors of Outcomes in Chronic Aortic Regurgitation
In a large cohort of asymptomatic patients with hemodynamically significant chronic aortic regurgitation, volumetric left ventricular size and function measurements were equally discriminant in identifying patients at higher risk for mortality vs. traditional linear measurements.
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What Causes MINOCA?
A systematic imaging protocol of coronary angiography, optical coherence tomography, and cardiac MRI in women clinically diagnosed with myocardial infarction with non-obstructive coronary artery disease revealed a cause in 84%, with three-quarters exhibiting an ischemic etiology.
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Analysis Details the Burdens
of Prior AuthorizationAdministrative hassles and confusion, along with delays and denials, push providers and patients alike to the brink.
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Biden-Harris Healthcare Team
Takes ShapeFauci moves front and center, Obama-era surgeon general returns.
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CMS Finalizes 2021 Physician Fee Schedule, Tinged with a Bit of Controversy
A budget neutrality provision leads industry groups to cry foul over Medicare cuts.
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EDs See Decrease in Low-Severity Illnesses, More Advanced Imaging
Perceived litigation risk has been often cited as one of the top reasons for ordering low-value imaging in many settings, including the ED. Higher costs and more radiation exposure (and hospitalizations) probably could have been avoided in many cases. Yet EPs know it is possible they will be sued for failing to order a diagnostic test.
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Home Monitoring to Determine Hospitalization Needs Among Discharged COVID-19 Patients
Discharging patients with a low-cost tool to monitor their own health can improve patient safety outcomes.