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A new selective phosphodiesterase type 5 (PDE5) inhibitor has been approved for treating erectile dysfunction (ED). Avanafil was developed by Mitsubishi Tanabe Pharma Corporation in Japan and is manufactured in Japan and marketed by Vivus, Inc., as Stendra.
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Vitamin D deficiency is associated with a significant risk of cardiovascular disease and reduced survival. Vitamin D supplementation improved survival, especially in patients with documented deficiency.
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The authors concluded that systematically obtaining family history identifies more subjects with high CV risk who may benefit from more aggressive preventive interventions.
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In a prospective study of nearly 5000 postmenopausal women, it was determined that it would take 16.8 years to develop osteoporosis in 10% of women with normal bone mineral density. The authors conclude that repeat screening in women without new risk factors can be delayed for at least 15 years.
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Within a few years after the initiation of diagnostic X-rays, toxic effects were noted, including increased risk for skin cancer, leukemia, dermatitis, and cataracts. In this early period, doses of X-ray, especially from fluoroscopy, were high. Protective devices for patients as well as persons occupationally exposed to diagnostic radiation demonstrably reduced such adverse consequences.
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The ED is a common setting for the initial evaluation of emotional and behavioral disorders, including suicidal behavior or attempts. In the United States, approximately 2 million adolescents attempt suicide each year. As the number of visits by adolescents to the ED rises and the availability of outpatient mental health services diminishes, the ED physician must be not only able to stabilize the patient medically, but also should be comfortable with differentiating organic from psychiatric disease, performing a targeted psychosocial interview, initiating treatment, and arranging for disposition.
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Sexually transmitted diseases (STDs) are frequently encountered in clinical medicine. According to the Centers for Disease Control, approximately 2.8 million infections with Chlamydia trachomatis and 700,000 infections with Neisseria gonorrhea occur annually in the United States.
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Knowledge of pediatric-specific antimicrobial susceptibility data improves prescribing selections of empiric antibiotic treatment. Providers should advocate for availability of pediatric-specific antimicrobial susceptibility data wherever practical.
