Primary Care/Hospitalist
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Low TMAO for a Healthy Heart
The gut microbial metabolite trimethylamine N-oxide (TMAO) is a predictor of coronary artery disease (CAD). Long-term changes in TMAO is a predictor of CAD and speaks to the benefits of a plant-based diet to prevent heart disease.
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Cholesterol Levels and Predicted Survival Rates Among Elderly Women
Researchers found neither low levels of high-density lipoprotein nor high levels of low-density lipoprotein were associated with predicted survival in older women. This finding is consistent with other studies of cholesterol and mortality in the elderly.
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Cannabis for Mental Health Disorders: Follow the Evidence
In a review of 83 eligible studies, researchers found little evidence to support the efficacy of cannabinoids to treat depressive disorders, anxiety disorders, or several other mental health disorders. There is low-grade evidence that pharmaceutical cannabis may help improve symptoms of anxiety in patients with a comorbid medical condition.
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Incidence of Cardiovascular Disease and All-Cause Mortality: Does the Type of Meat Consumed Matter?
Investigators found consuming more processed meat, unprocessed red meat, or poultry (but not fish) was closely connected to a higher risk for incident cardiovascular disease. Meanwhile, consuming processed meat or unprocessed red meat (but neither fish nor poultry) was strongly associated with a higher risk of all-cause mortality.
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Cannabis in the Treatment of Headache and Migraine
The authors of this observational study found nearly a 50% reduction in self-reported headache and migraine severity following use of inhaled medicinal cannabis.
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A Roadmap for Tobacco Cessation Treatment
In the United States, about 500,000 people die each year from tobacco-related illness. Although tobacco use has decreased in recent years, its devastation continues to plague many, especially those marginalized by social or health disparities.
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Bempedoic Acid (Nexletol)/Bempedoic Acid and Ezetimibe (Nexlizet)
Bempedoic acid and bempedoic acid/ezetimibe should be prescribed as a supplement to diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who need additional LDL-C lowering.
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Heart Rate and Diastolic Blood Pressure in Chronic Aortic Regurgitation Patients
A retrospective observational study of patients with moderate to severe aortic regurgitation showed the independent predictive value of diastolic blood pressure and resting heart rate for all-cause mortality under medical management.
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Using Apple Cider Vinegar for Weight Management on a Restricted Diet
Supplementation with 30 mL of apple cider vinegar combined with a restricted calorie diet may lower body weight, body mass index, and serum triglyceride levels in people with obesity.
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Are Epidural Steroid Injections Cost-Effective?
In a retrospective review of patients treated for low back pain and lumbar radiculopathy at the Cleveland Clinic, at three- and six-month follow-up, epidural steroid injections were no better than conservative therapies in quality of life measures or overall cost of medical care.