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Appropriate use of anticoagulants offers both opportunity and challenge for the primary care clinician. This discussion is directed toward simplifying the pathophysiology and effective use of anticoagulation in the primary care setting.
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The most commonly prescribed statins have a low incidence of rhabdomyolysis, according to the results a new study of more than 250,000 patients.
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Neurologic emergencies of pregnancy range from life-threatening conditions such as eclamptic seizures to self-limiting disorders like meralgia paresthetica. This discussion will include those neurologic disorders directly resulting from pregnancy or the puerperium, those that are pre-existing conditions but now affect the pregnant patient or are affected by the gravid state of the patient, and those disorders that are not directly related to the pregnancy but may first become apparent during the gravid state.
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Statins lower the levels of c-reactive protein (CRP) as well as the levels of LDL cholesterol (LDL-C). Whether lowering the CRP affects the clinical outcomes of statin therapy has not previously been investigated.
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Although chronic oral antiarrhythmic prophylaxis and catheter ablation both enjoy great success for preventing recurrences of atrial fibrillation (AF), some patients are not appropriate candidates for either method, especially patients with infrequent recurrences of AF.
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Examining data from a 20-year time period, correlations were sought between antisecretory drug therapy and cumulative incidence of dysplasia. Incidence of dysplasia was significantly lower in patients who had received proton pump inhibitor therapy vs no therapy or H2-receptor antagonists.
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Increased hospitalizations for abnormal bleeding were found in new users of selective serotonin reuptake inhibitor (SSRI) antidepressants, with more risk associated with SSRIs containing greater degrees of serotonin reuptake inhibition.