Primary Care/Hospitalist
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Inappropriately Broad Empiric Antibiotics, Higher Mortality, and Community-Onset Sepsis
A retrospective cohort study revealed broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and were associated with worse outcomes and higher mortality.
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Thin Evidence Supporting the Obesity Paradox in STEMI
This largest-to-date analysis of six randomized studies of ST-elevation myocardial infarction revealed no association between body mass index and infarct size, one-year mortality, or heart failure hospitalization.
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The ABCs of CBD: The Fundamentals of Cannabidiol
Cannabidiol (CBD) is one of two major constituents of marijuana and is the non-psychoactive component of cannabis. As its popularity has grown, questions about CBD from patients to their primary care clinicians have increased dramatically. As a patient advocate interpreting the available evidence, the primary care clinician needs to recognize how CBD differs from marijuana, what its clinical utility might be, and what its risks are.
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DASH Is Revisited and Updated, Lowering Subclinical Cardiac Injury Markers
In individuals without pre-existing cardiovascular disease, the Dietary Approaches to Stop Hypertension diet plan and a diet consisting of fruits and vegetables, given over eight weeks, lowered biomarkers for cardiac strain and injury.
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The Relationship Among Step Count, Step Intensity, and Mortality in Adults
The authors of this observational study of 4,840 adults show an association between higher number of steps taken daily and lower all-cause mortality, lower mortality from cardiovascular disease, and lower mortality from cancer, but no association between intensity of steps and mortality in any of those areas.
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Insulin Lispro-aabc Injection (Lyumjev)
Lyumjev is indicated to improve glycemic control in adults with diabetes mellitus.
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Clostridioides difficile: Risk Factors for Disease
Approximately one-tenth of asymptomatic patients with Clostridioides difficile colonization went on to develop disease. A wide range of antibiotic exposures represent a significant risk.
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Benefits of Exercise in Established Atrial Fibrillation
A large, long-term, prospective, Norwegian population study of patients with established atrial fibrillation revealed physical activity at or above recommended levels reduces all-cause and cardiovascular mortality vs. atrial fibrillation patients who are inactive.
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Eat Flavonoids for a Healthy Brain
An investigation of the Framingham Offspring Study revealed a higher intake of dietary flavonoids found in plants is associated with modest slowing of age-related dementia.