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This study assessed the effectiveness of oral melatonin taken in different dosage regimens for alleviating jet-lag after air travel across several time zones.
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Debate over the cardiovascular effects of COX-2 inhibitors has raged
for more than a year since a special communication was published in
JAMA last August suggesting an increase in cardiovascular events with
rofecoxib (Vioxx). Now a large retrospect, the cohort study from the
Tennessee Medicaid program seems to confirm the prothrombotic effects
of rofecoxib, at least in high dose.
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GlaxoSmithKline is expected to launch a new drug for benign prostatic hypertrophy in December. Dutasteride is a 5 alpha-reductase inhibitor, which was previously approved in November 2001 but not launched.
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Among patients being evaluated for chronic cough, women are more sensitive than men to inhalation of tussive agents.
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Expanding upon their earlier study that demonstrated that spouses of hypertensive patients are more likely to be hypertensive themselves, these British researchers studied couples to determine whether other illnesses exhibited the same association.
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Sleep disorders are extremely common and the primary care physician (PCP) can play an important role in their identification and management. The PCP is the first line of defense for identifying patients with sleep disorders and initiating appropriate evaluation and managing long-term treatment.
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There is evidence that diet could play a role in Alzheimer's disease (AD) risk. This epidemiologic study examined the risk of AD between quartiles of calorie, carbohydrate, fat, and protein intake after adjusting for confounders.
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Ambulatory blood pressure monitoring is a useful adjunct for evaluating white coat hypertension, but little is known about its effect on BP. Thus, Hermida and associates from Spain studied 538 patients with mild-to-moderate office hypertension using ABPM for 48 hours.
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There appears to be an increase in ovarian cancer with long-term estrogen-only hormone replacement therapy.