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A randomized study of treatment of septic arthritis in children 3 months to 15 years of age demonstrated that 10 days of treatment, with an initial 2-4 days intravenously followed by oral therapy, was sufficient for most cases, regardless of the infecting pathogen or site of infection.
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The role of intensive antiplatelet therapy for prevention of vascular events in patients with atrial fibrillation remains controversial. The Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE) trio of studies is an attempt to clarify this issue.
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Lay books and web sites tout the benefits of progesterone cream for use in menopausal women. A Google search reveals roughly 338,000 results when the term "progesterone cream" is entered.
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Two systematic reviews concluded that acupuncture is somewhat beneficial in the prophylactic treatment of both migraine and tension-type headaches.
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In the popular press, there has been a recent focus on "superfoods," or foods that contain high levels of nutrients that some people feel have the best evidence for the prevention or treatment of various medical conditions.
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The ACTIVE Investigators. Effect of clopidogrel added to aspirin in patients with atrial fibrillation.
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The FDA has approved the first oral, selective vasopressin V2-receptor antagonist for the treatment of hypervolemic and euvolemic hyponatremia.
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A polypill consisting of low doses of thiazide, atenolol, ramipril, simvastatin, and aspirin administered to 2053 subjects in 50 centers in India was effective in reducing multiple risk factors and cardiovascular risk.
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A review of large randomized clinical trials for type 2 diabetes controlling HbA1c as low as 6.5-7.0% showed many consequences, but uncertain benefits. A new approach to type 2 diabetes should include individualized HbA1c targets along with cardiovascular risk reduction reflecting patients' values and preferences, and caution is urged in using these HbA1c values as performance measures to indicate inadequate care.