This basic science paper explores the role of the tumor microenvironment in the development of tumor resistance to chemotherapy. Two distinct fatty acid molecules, endogenously produced by cancer cells in response to platinum-based chemotherapy drugs, were found to confer significant tumor chemoresistance. Remarkably, these two fatty acids also were shown to be present in several commercial fish oil products, and, of potential import to clinicians, the oral administration of small amounts of these fish oils induced tumor resistance to cisplatin in a mouse tumor model.
In postmenopausal women, constipation is associated with having major risk factors for cardiovascular disease and increased cardiovascular risk.
This is the second in a three-part series about the design and conduct of clinical research.
Sickle cell disease celebrated its 100th anniversary last year, prompting consideration of what has transpired for those with the disease since its description by Dr. James Herrick in 1910.
The skin is a dynamic organ, accounting for 15-20% of total body weight, and exhibits many functions such as protection against thermal and mechanical insults and against pathogenic microorganisms.