Primary Care/Hospitalist
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Clinical Briefs
This article covers the following topics: the saga of homocysteine and vasculopathy; roflumilast for acute exacerbations in COPD; and treatment of OSA reduces risk of repeat revascularization after PCI.
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Ivabradine Tablets (Corlanor ®)
Ivabradine's effect in reducing heart rate, by acting on the SA node, was most prominent at a higher heart rate, thus minimizing the risk of bradycardia.
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Clindamycin vs. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Infections
Cure rates did not differ between the treatments and rates of adverse events were similar in the two groups.
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Utility of the New Cholesterol Guidelines
The risk:benefit ratio is much better for moderate- than high-intensity statins.
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Risk of NSAID Use in Patients Receiving Antithrombotic Therapy After Myocardial Infarction
The use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events, even after short-term treatment.
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Severe Alcoholic Hepatitis: Prednisolone or Pentoxifylline?
ABSTRACT & COMMENTARY: A clinical trial studied short- and medium-term mortality in patients admitted to the hospital for severe alcoholic hepatitis.
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Wide Tachycardia in a Patient with Chest Pain
The 12-lead ECG and accompanying long lead II rhythm strip in the Figure was obtained from a 70-year-old woman with chest pain. She was hemodynamically stable at the time this ECG was recorded. What is the rhythm? -
Clinical Briefs
Accumulation of briefs: Consequences of NSAID Use in Patients Receiving Post-MI Antithrombotic Prophylaxis, Psoriasis Is Associated with Insulin Resistance, and Difficult Questions About Testosterone and Mortality
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Steroids for Severe Community-Acquired Pneumonia: More Evidence or More Uncertainty?
Community-acquired pneumonia (CAP) is the leading cause of mortality from infection in industrialized countries, and treatment failure occurs in 10-20% of cases despite appropriate antibiotic therapy. Thus, effective treatment strategies that reduce the burden of CAP would have a major impact on public health. Several previous studies that investigated the role of corticosteroids in CAP produced mixed results. Torres and colleagues hypothesized that corticosteroids modulate the immune response in severe CAP, thereby decreasing treatment failure.
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Effects of Lifestyle Modifications on the Coronary and Carotid Atherosclerotic Burden
A look at how lifestyle changes, including dietary modifications and regular exercise, impact therapy for atherosclerotic cardiovascular disease.