Primary Care/Hospitalist
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Pharmacology Update: Memantine HCl and Donepezil HCl Capsules (Namzaric™)
The addition of memantine to a stable dose of an acetylcholinesterase inhibitor may improve cognitive performance.
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PCSK9: A Major New Advance in Cholesterol-lowering Therapy
When added to statin therapy at the maximum tolerated dose, the PCSK9 inhibitor alirocumab reduced low-density lipoprotein cholesterol levels by 62% and also reduced the rate of occurrence of cardiovascular events.
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Obesity Paradox and Diabetes
In a prospective cohort study of overweight or obese type 2 diabetics, being overweight was associated with a lower mortality risk, but being obese was not.
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Can CPAP Treatment Prevent Dementia?
ABSTRACT & COMMENTARY: Older people with sleep apnea had onset of cognitive decline at an earlier age than those without sleep apnea.
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ECG Review: Is There Complete AV Block or Any Block at All?
We summarize the five parameters to assess in the interpretation of any cardiac rhythm by the saying, “Watch your Ps and Qs — and the 3Rs.”
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Clinical Briefs
In this issue: Carbon monoxide toxicity in the elderly; Does hypovitaminosis D increase risk of atrial fibrillation in hypertensive patients?; and reflections on the consequences of morning BP surge.
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Liraglutide Injection (Saxenda®)
The glucagon-like peptide (GLP-1) receptor agonist, liraglutide is now approved for weight management in adults.
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Inpatient and Outpatient Care Providers: Why Can’t We Just Work Together?
The authors of this paper did a qualitative study to analyze the barriers and solutions to care coordination between hospitalists and primary care providers in North Carolina.
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Efficacy of Folic Acid Therapy in Primary Prevention of Stroke
Among adults with hypertension in China without a history of stroke or myocardial infarction, the combined use of enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke.
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Drug-related HIV outbreak spurs CDC to issue nationwide alert
The CDC has issued a national health advisory in light of its investigation with the Indiana State Department of Health of a large outbreak of recent HIV infections among persons in Indiana who inject drugs.