Primary Care/Hospitalist
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Prevention of Proton Pump Inhibitor-induced Bowel Symptoms with Probiotics
The administration of a Lactobacillus paracasei strain (F19) twice daily and 3 times per week for 6 months appears to reduce the incidence of bowel symptoms (bloating and flatulence) and reduce changes in bowel habits (increased stool frequency and loose stools) but not abdominal pain in patients taking proton pump inhibitors.
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Sustainable 25(OH)D Levels? Choose Vitamin D3 over D2
Compared to vitamin D2, daily supplementation with vitamin D3 appears to sustain serum 25(OH)D levels even after discontinuation of supplementation in healthy adults.
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Spiritual Interventions for Patients with Cancer
A systematic meta-analysis investigating the effects of spiritual intervention in patients with cancer found that spiritual interventions had significant moderate effects on spiritual well-being, meaning of life, and depression.
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Integrative Therapies for Fibromyalgia – What News?
Although fibromyalgia remains a challenging management problem in clinical medicine, significant progress has been made in the last five years in terms of identifying underlying neurobiological abnormalities, which may one day elucidate the pathophysiology of the disorder.
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Risk of NSAID use in patients receiving antithrombotic therapy after myocardial infarction
Among patients receiving antithrombotic therapy after MI, the use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events, even after short-term treatment.
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Early, goal-directed therapy of septic shock
One thousand two hundred sixty patients with early septic shock were randomized to early, goal-directed therapy vs. usual care. Hemodynamic management according to a strict protocol did not lead to an improvement in outcome.
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Hospital wards with higher rates of antibiotic prescribing associated with increased risk for C. diff infection
A retrospective observational study found that among hospitalized patients, ward-level antibiotic prescribing was associated with a significantly increased risk for C. difficile infection beyond what would be expected with patient-level antibiotic use.
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Vasospastic angina with myocardial infarction – more dangerous than once thought?
Patients with vasospastic angina and a type II myocardial infarction have a worse prognosis than previous believed.
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Do I need atypical coverage for all non-ICU hospitalized patients with community-acquired pneumonia?
Is the accepted treatment for CAP enough, or could we do more?
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Clinical Briefs
Updates on treatment of depression, the prevention and treatment of osteoporosis, and subclinical thyroid dysfunction as it relates to fracture risk.