Primary Care/Hospitalist
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SPRINT: The Systolic Blood Pressure Trial or ‘How Low Do You Go?’
Designed to see if lower blood pressures reduced the risk of blood pressure-related health outcomes, the NIH ended the SPRINT trial early and issued a news release that a lower blood pressure target significantly reduces cardiovascular complications in adults age 50 and older with high blood pressure.
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Valve Disease and Thromboembolic Risk
The CHA2DS2-VASc score for the prediction of stroke and other thromboembolism risk in patients with atrial fibrillation has been validated in patients with non-valvular atrial fibrillation.
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Using Procalcitonin to Differentiate Bacterial from Viral Meningitis
SYNOPSIS: A meta-analysis based on nine studies found an elevated serum procalcitonin to be an accurate test for differentiating bacterial from viral meningitis in adults.
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Could High-flow Oxygen Therapy Impact Acute Respiratory Failure Management?
SYNOPSIS: Managing acute hypoxemic respiratory failure with high-flow nasal cannula (HFNC) significantly reduced intubation rates compared to standard oxygen (O2) mask delivery and non-invasive ventilation among patients whose arterial O2 tension to inspired O2 fraction ratio (PaO2/FiO2) was < 200. Among all study patients, hospital mortality was lower in the HFNC group.
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Role of Transthoracic Echo in Staph Bacteremia
In patients without community-acquired Staph bacteremia, a high-risk cardiac condition, or IV drug use, a negative transthoracic echo excluded infective endocarditis.
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The Pros and Cons of Central Venous Catheterization Sites
ABSTRACT AND COMMENTARY: Improper placement can lead to a deep vein thrombosis or a blood stream infection. Here's guidance on doing it right.
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ECG Review: A 43-Year-Old Man with Atypical Chest Pain
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Clinical Briefs
In this section: reversing the anticoagulant effect of dabigatran; considering the likelihood of occult cancer causing unprovoked deep venous thrombosis; and cardiovascular autonomic neuropathy occurs earlier in type 2 diabetes.
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Evolocumab Injection (Repatha)
Evolocumab is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients who require additional lowering of LDL-C.
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Vitamin D and Diabetic Neuropathy
Vitamin D deficiency may exacerbate the clinical manifestations of diabetic neuropathy, and supplementation with vitamin D3 may be beneficial.