Primary Care/Hospitalist
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Mefloquine: Still Effective and Still Safe for Malaria Chemoprophylaxis
Mefloquine is known as an effective agent for malaria chemoprophylaxis. However, concerns about serious adverse effects have limited its use. Now, a careful review of data suggests that fatal outcomes related to mefloquine prophylaxis are very rare.
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What Form of AV Block?
The long lead II rhythm strip shown in the figure was obtained from a hemodynamically stable patient. The rhythm was diagnosed as showing second-degree AV block, Mobitz Type II. Do you agree with that assessment?
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Clinical Briefs
In this section: comparing GLP-1 agonists; weighing two treatments for extended venous thromboembolism; and considering fracture risks possibly associated with inhaled corticosteroids.
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Ibalizumab-uiyk Injection (Trogarzo)
Ibalizumab-uiyk, in combination with other antiretrovirals, is indicated for the treatment of HIV-1 in heavily treatment-experienced adults with multidrug-resistant HIV infections failing their current regimens.
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After Myocardial Infarction, Increased Risk for Ischemic Stroke Persists for 12 Weeks
This study establishes that the elevated short-term risk of stroke extends beyond 30 days and remains elevated for up to 12 weeks following acute myocardial infarction.
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Stroke Risk in Atrial Fibrillation: A Moving Target?
An investigation of patients in a national database with atrial fibrillation, no comorbidities, and not on aspirin or anticoagulants showed that the clinical features that make up the CHA2DS2-VASc score change over time and can increase a patient’s risk for stroke, which could affect therapy decisions. Thus, the CHA2DS2-VASc score should be reassessed periodically and appropriate therapeutic actions taken promptly.
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Elderly May Not Benefit From Statins for Primary Prevention
In an examination of the data from the much-publicized Systolic Blood Pressure Intervention Trial (SPRINT), the author found no benefit of statin therapy for primary prevention of cardiovascular events or all-cause mortality.
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Research Examines Use of Tenofovir Gel in Women
As HIV infection continues to be a major public health issue, tenofovir gel is being researched as a topical pre-exposure prophylaxis strategy for HIV prevention in women.
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Provider Training May Boost Rates of HPV Vaccination
Results of a recent study indicate a training intervention to aid provider communication about HPV vaccines with teen patients and their parents increased initiation and completion of the vaccine series.
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Get up to Speed in Addressing Urinary Tract Infections
Research presented at the 2017 annual meeting of the Infectious Diseases Society of America indicates that women at risk of urinary tract infection (UTI) who increased their water intake by drinking an additional three pints of water a day were almost half as likely to get infections as women who did not.