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Autologous CD4+ T-cells modified to delete CCR5 by Zinc-finger nuclease (ZFN) were infused into 12 HIV-infected patients. Cells survived in the circulation of patients and provided some control of viral replication and immune reconstitution after interruption of antiretroviral therapy.
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TB rates among pre-school aged children in the United States are 32 times higher in foreign-born children and six times higher in U.S.-born children with at least one foreign-born parent, compared to U.S.-born children with U.S.-born parents.
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Hepatitis C virus (HCV) infection is an important global health issue that affects approximately 184 million people. Conventional therapy for HCV with interferon and ribavirin is associated with high rates of virological failure and severe side-effects.
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As many as 10% may be non-responders
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Cidofovir (CDV), which was licensed in the United States in 1996 for the treatment of cytomegalovirus retinitis, has been used successfully in a number of other viral infections, including those due to drug-resistant herpes simplex, varicella-zoster, and adenovirus.
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Anaerobes were not found to play an important role in the etiology of pneumonia in nursing home residents with an increased risk of aspiration.
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Organisms that may only be isolated by using coculture with amoeba and that are present in hospital water supplies may be implicated in some cases of ventilator-associated pneumonia.
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Neither adding a single dose of ceftriaxone to a 10-day course of doxycycline nor extending the duration of doxycycline therapy to 20 days is better than a straightforward 10-day course of oral doxycycline in the treatment of patients with erythema migrans.
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