Pain
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Migraine With Aura, Stroke Risk, and Biomarkers
A longitudinal cohort study of twins found no increased stroke risk related to migraine overall, but there was a modestly increased risk for stroke related to migraine with aura. Familial factors and vascular biomarkers associated with migraine with aura may explain its correlation with vascular disease.
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Deep Brain Stimulation May Offer Hope in Treating Post-stroke Pain
This trial of deep brain stimulation of the ventral striatum/anterior limb of the internal capsule improved several measures of the affective sphere of pain in those suffering from post-stroke pain, despite no significant improvement seen in the pain disability index.
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Migraine and the Blood-brain Barrier
During spontaneous attacks of migraine with visual aura, magnetic imaging studies indicate that the blood-brain barrier remains intact and the pons is activated.
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Spinal Manipulative Therapy for Acute Low Back Pain
Spinal manipulative therapy for acute low back pain may provide some benefit, but carries a significant risk of treatment-associated pain.
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Medication for Acute Low Back — A Randomized Clinical Trial
In a trial comparing naproxyn alone to combinations with cyclobenzaprine or oxycodone/acetaminophen in patients with acute low back pain, there was no difference in outcome after 1 week.
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Is Early MRI Warranted for Back Pain in the Elderly?
In an analysis of a large dataset from several large integrated health care systems of patients older than 65 years of age with new-onset low back pain, early spine imaging did not alter management or outcomes, but added considerable cost to their care.
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Update in Treating Neuropathic Pain
In an exhaustive review of the literature with a meta-analysis, the following medications were found to be most efficacious in the treatment of neuropathic pain: gabapentin, pregabalin, serotonin-noradrenaline reuptake inhibitors including duloxetine or venlafaxine, and tricyclic antidepressants.
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Gabapentin vs. Propranolol for Essential Tremor