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These data support the hypothesis that favorable survival that is associated with optimal debulking of advanced ovarian cancers is due to, at least in part, the underlying biologic characteristics of these cancers.
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The canceled estrogen-progestin arm of the Womens Health Initiative reported an increase in ovarian cancer that was not statistically significant, prompting the authors to say: The possibility of an increased risk of ovarian cancer incidence and mortality remains worrisome and needs confirmation.
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Abdominal myomectomy might improve reproductive outcome in cases of intramural or subserosal fibroids especially if the patient is less than 30 years of age and the myoma is single.
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It is hard to believe, but whom, how, and when to screen for thyroid disease is a highly controversial topic. The controversy is fueled by uncertainty about which populations are at risk, short-term cost vs benefit considerations, lack of consensus about when to initiate treatment, whether to use a mix of thyroxine and thyronine, and debate about the long-term risks of treating vs not treating asymptomatic individuals.
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Hypothyroidism and Pregnancy; Anti-Depressants and the Risk of Suicide; FDA Actions; Brief Notes.
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B-type natriuretic peptide (BNP) is a biomarker released by cardiac ventricular myocytes. Its usefulness is mainly in the emergency room for the evaluation of acute dyspnea, to evaluate for cardiac failure. BNP may have usefulness as a screening test for preclinical heart disease, for risk stratification and for guidance with therapy.
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Although regular aspirin use reduces the risk for colorectal adenoma formation as shown in previous randomized-controlled trials, the protective effect now seems to be greatest at substantially higher doses (> 14 standard tablets/week) than currently recommended for cardiovascular prophylaxis.
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The FDA has approved a combination product of amlodipine and atrovastatin for the treatment of patients with comorbid hypertension and hypercholesterolemia.
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The ECG shown in the Figure was obtained in the emergency department (ED) from a 61-year-old woman with a history of significant hypertension. She was alert, oriented, and not in acute distress at the time this tracing was recorded, although she was markedly hypertensive and experiencing some chest pain. No prior ECG was available. The patient was treated in the ED with several doses of Adenosine and eventually converted to sinus rhythm. Your thoughts on the rhythm and the management?