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Full February 15, 2003 Issue in PDF

Smoking and Lung Function of Lung Health Study Participants after 11 Years

Continuing smokers from the Lung Health Study 1 followed for a period of 11 years demonstrated a greater decline in lung function when compared to sustained quitters.

Use of Selective Serotonin Reuptake Inhibitors and Risk of Upper Gastro-intestinal Tract Bleeding

SSRIs increase the risk of upper gastrointestinal bleeding, and this effect is potentiated by concomitant NSAID or aspirin use.

Fluoroquinolones and Tendinopathie

The excess risk of Achilles tendon disorders attributable to fluoroquinolone use was estimated to be 3.2 cases per 1000 patient-years, with most of that increase accounted for by patients 60 years of age and older who concomitantly receive corticosteroids.

Clinical Briefs

Prostate Cancer Screening; Can We Trust Home BP Measurement?; Systolic and Diastolic Dysfunction

Pharmacology Watch: FDA Issues ‘Black Box’ Warning Based on WHI Study

FDA Issues Black Box Warning Based on WHI Study; ALLHAT: Thiazide for Hypertension Treatment; Candesartan Effective Against Migraines; Cough! No Cold Relief from Echinacea; COX-2 Inhibitors and GI Benefits Could Be Overrated; FDA Actions

Make New Friends, but Keep the Old

Thiazide diuretics should be the first-step antihypertensives because they are less expensive and more effective than calcium channel blockers or ace inhibitors.