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Pravastatin given for 3 years reduced the risk of coronary disease in elderly individuals. The PROSPER study therefore extends to elderly individuals the treatment strategy currently used in middle aged people.
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The FDA has approved cyclosporine ophthalmic emulsion for the treatment of dry eyes due to keratoconjuctivitis sicca (KCS) and associated reduced tear production. Cyclosporine is an immunomodulating agent that increases tear production in patients with KCS.
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Ice Cream-Evoked Headaches Study: A Randomized Trial of Accelerated vs Cautious Ice Cream Eating Regimen; Treatment of Antidepressant-Associated Sexual Dysfunction with Sildenafil; Prophylactic Treatment of Migraine with an Angiotensin II Receptor Blocker
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Screening for lung cancer with helical CT has high costs and uncertain benefits.
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Current guidelines for NSAID use in patients at high risk for ulcer disease recommend use of NSAIDs selective for cyclo-oxygenase-2 inhibition or nonselective NSAIDs plus a proton pump inhibitor. This study compared diclofenac plus omeprazole with celecoxib in patients with previous GI hemorrhage. Neither regimen successfully prevented rebleeding, and both exhibited significant toxicities.
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Treatment with natalizumab, an antibody to a4 integrin, led to fewer inflammatory brain lesions and fewer relapses in patients with relapsing multiple sclerosis.
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The potassium sensitivity test (PST) was administered to 244 patients with pelvic pain and 47 control patients by enrolling gynecologists at 4 separate facilities. Previous work by these physicians had shown that the test appears to identify the presence of interstitial cystitis (IC) by detecting abnormal permeability of the bladder epithelium.
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There are 2 important potential uses for the measurement of testosterone levels: 1) to monitor the dosage of testosterone supplementation; and 2) to diagnose hyperandrogenism, whatever the cause. Unfortunately, the measurement of testosterone is particularly difficult in women because of the low circulating levels.
