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Now that male circumcision has been associated with a lower risk for HIV infection in international observational studies and in three randomized controlled clinical trials, international health officials are looking at options in making it more available to men at risk.
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Through a small but exquisite study, the authors of this investigatory intervention trial provide a plausible subcellular explanation for massage therapy's purported benefits on injured muscle using muscle biopsy and subsequent gene profiling. The application of similar study techniques might be expected in future studies of other CAM therapies directed against pain.
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Evidence for the use of probiotics in a variety of medical conditions continues to accumulate.
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The results of the PEARL I and PEARL II studies were published recently in the same issue of the New England Journal of Medicine. Both were well-designed, randomized, controlled, double-blinded studies that assessed the safety and efficacy of ulipristal acetate (UPA) for the treatment of symptomatic uterine fibroids.
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In this issue: Statins and diabetes risk; new treatment guideline for diabetes; new pertussis vaccine recommendation; antibiotics and rhinosinusitis; fluoroquinolones and cystitis; and FDA actions.
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It has been long recognized that thrombocytosis (defined as a platelet count > 450,000/mm3) frequently accompanies the diagnosis of advanced cancer and has been associated with poor outcomes.
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The authors conducted a double-blind, randomized, controlled trial to determine whether the postoperative use of a levonorgestrel intrauterine system (LNG-IUS) was an effective treatment for chronic pelvic pain in women with endometriosis.