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The well-known mantra of primary ovarian cancer management is surgery. The procedure has modified little in the last 30 years as the goal in advanced cases has been cytoreduction and, in seemingly early cases, it has been accurate staging.
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Rosen and colleagues reported the results of a 1-year, multicenter, randomized, clinical trial comparing the once-a-week administration of alendronate and risedronate to postmenopausal women with osteoporosis (the FACT study-Fosamax Actonel Comparison Trial). The 1053 women were treated with either 70 mg alendronate or 35 mg risedronate weekly, taken with a full glass of water after fasting, and in the upright position after awakening in the morning.
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Reproducibility of complex proteomic signatures in detecting early stage ovarian cancer has proven to be a significant challenge in the field of biomarker discovery. Although early reports of proteomic profiling demonstrated near 100% sensitivity and specificity in discriminating ovarian cancer from non-cancer, the ability to reproduce these results across datasets has been difficult.
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This meta-analysis of 36 articles culled from a pool of 779 publications included 20 different populations. Four were cohort studies and 16 were case-controlled. Among the cohort studies, the pooled odds ratio (OR) showed no increased risk of stroke with oral contraceptive use.
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The FDA has asked Pfizer to withdraw valdecoxib (Bextra) from the market due to safety concerns.
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A new therapeutic agent has been approved for the treatment of age-related macular degeneration.
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Screening for bipolar disorder in primary care settings can aid in its diagnosis.
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In patients with vascular disease or diabetes mellitus, long-term vitamin E supplementation does not prevent cancer or major cardiovascular events and may increase the risk for heart failure.
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The 12-lead ECG in the Figure was obtained from a 69-year-old woman with a history of a previous large myocardial infarction. She was aware of an extra beating of her heart, but was otherwise asymptomatic at the time this tracing was recorded. How would you interpret this tracing in view of this presentation, her prior history, and the knowledge that the patient was known to have complete right bundle branch block on prior ECG?