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Golimumab is indicated for the treatment of adults with moderately to severely active rheumatoid arthritis in combination with methotrexate (MTX), active psoriatic arthritis, and active ankylosing spondylitis with or without methotrexate or other non-biologic disease-modifying antirheumatic drug (DMARD).
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Insomnia persists.
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Despite a clear-cut association between asthma and gastroesophageal reflux, aggressive PPI treatment had no clinical effect on poorly controlled asthma.
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Patients with chronic heart failure (CHF) report progressively worse dyspnea with exercise, ranging from Class I NYHA (symptoms only present with strenuous exercise) to Class IV NYHA (symptoms present with any activity, even at rest).
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Brown adipose tissue is involved in temperature regulation, and relates to metabolic rate and body mass index. Its activity appears to be reduced in people who are obese.
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A survey of U.S. primary care physicians found that although most recommend weight loss to their obese patients, they do not utilize current evidence-based recommendations, and they underestimate the therapeutic effects of small weight losses.
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Most clinicians maintain a fairly glucose-centric view of diabetes. That is, we have made the assumption that the most visible derangement in diabetes, hyperglycemia, is the culprit producing vascular disease.
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Lack of sleep impairs the immune system and lowers resistance to viral illness. The quality of sleep is important. Those volunteers who spent less than 92% of their time in bed asleep were five-and-a-half times more likely to become ill than those who were asleep for at least 98% of their time in bed.