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Stopping Aspirin Before Surgery; The Sponge Returns; Preventing Metabolic Syndrome; FDA Actions
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Odvina and colleagues report 9 patients (8 women and 1 man) who sustained spontaneous, atraumatic, nonspinal fractures while on alendronate treatment. One patient also had a lumbar spinal fracture, but almost all of the fractures occurred in skeletal sites rich in cortical bone. In addition, 6 of the 9 patients displayed either delayed or absent fracture healing.
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Blumenthal and colleagues point out in the introduction that psychological factors are recognized to play a significant and independent role in the development of ischemic heart disease and its complications, but it is not clear if psychological or behavioral interventions will reverse established cardiac conditions. They undertook the present study to test the hypothesis that stress reduction would lead to better cardiovascular health in individuals with established ischemic heart disease.
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In 1985 5.6% of pregnant patients were 35 years of age or older, and in 2002 that figure rose to 12.5%. It is estimated that last year 20% of the pregnant population was older than 34 years of age.
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Is Holding NSAIDs Prior to Surgery Rational?; Low-Dose Aspirin: Men vs Women; FDA Actions
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The rationale for this study is interesting. As the trial investigators point out, oxidative injury has been implicated as a key mechanism, leading to atherosclerotic cardiovascular disease and cancer.
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Given the widely variant survival characteristics of women with advanced ovarian cancer, discrete quantifiable differences in tumor biology must exist. Heretofore, accurate characterization has been elusive.
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Bath and gray from the division of stroke Medicine in the Queens Medical Centre, University of Nottingham, performed a meta-analysis of the published literature regarding the association between postmenopausal hormone therapy and risk of stroke.
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