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Drug Labels A Prescription for Misunderstanding?; Osteonecrosis of the Jaw New Side-Effect to Bisphosphate Use; Beta-Blockers and Depression Unlinked?; FDA Actions
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Kahlenborn and colleagues performed a meta-analysis of case-control studies published after 1979 that focused on the use of oral contraceptives and the risk of premenopausal breast cancer.
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The resection of tumor nodules (or cytoreduction) before primary chemotherapy has been linked closely with survival in patients with advanced epithelial ovarian cancer. Chi and colleagues set out to evaluate the merits of cytoreduction completeness in a homogeneous cohort of ovarian cancer patients with bulky metastatic disease.
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The lead paper in the November issue of Obstetrics and Gynecology should stimulate lively discussion regarding the counseling of patients of advanced maternal age (AMA), and, if taken at face value, could impact the field of prenatal diagnosis, in general.
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This meta-analysis of 36 articles culled from a pool of 779 publications included 20 different populations. Four were cohort studies and 16 were case-controlled. Among the cohort studies, the pooled odds ratio (OR) showed no increased risk of stroke with oral contraceptive use.
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Reproducibility of complex proteomic signatures in detecting early stage ovarian cancer has proven to be a significant challenge in the field of biomarker discovery. Although early reports of proteomic profiling demonstrated near 100% sensitivity and specificity in discriminating ovarian cancer from non-cancer, the ability to reproduce these results across datasets has been difficult.
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Rosen and colleagues reported the results of a 1-year, multicenter, randomized, clinical trial comparing the once-a-week administration of alendronate and risedronate to postmenopausal women with osteoporosis (the FACT study-Fosamax Actonel Comparison Trial). The 1053 women were treated with either 70 mg alendronate or 35 mg risedronate weekly, taken with a full glass of water after fasting, and in the upright position after awakening in the morning.
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The well-known mantra of primary ovarian cancer management is surgery. The procedure has modified little in the last 30 years as the goal in advanced cases has been cytoreduction and, in seemingly early cases, it has been accurate staging.
