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Stopping Aspirin Before Surgery; The Sponge Returns; Preventing Metabolic Syndrome; FDA Actions
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The well-known mantra of primary ovarian cancer management is surgery. The procedure has modified little in the last 30 years as the goal in advanced cases has been cytoreduction and, in seemingly early cases, it has been accurate staging.
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Rosen and colleagues reported the results of a 1-year, multicenter, randomized, clinical trial comparing the once-a-week administration of alendronate and risedronate to postmenopausal women with osteoporosis (the FACT study-Fosamax Actonel Comparison Trial). The 1053 women were treated with either 70 mg alendronate or 35 mg risedronate weekly, taken with a full glass of water after fasting, and in the upright position after awakening in the morning.
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Reproducibility of complex proteomic signatures in detecting early stage ovarian cancer has proven to be a significant challenge in the field of biomarker discovery. Although early reports of proteomic profiling demonstrated near 100% sensitivity and specificity in discriminating ovarian cancer from non-cancer, the ability to reproduce these results across datasets has been difficult.
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This meta-analysis of 36 articles culled from a pool of 779 publications included 20 different populations. Four were cohort studies and 16 were case-controlled. Among the cohort studies, the pooled odds ratio (OR) showed no increased risk of stroke with oral contraceptive use.
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Bath and gray from the division of stroke Medicine in the Queens Medical Centre, University of Nottingham, performed a meta-analysis of the published literature regarding the association between postmenopausal hormone therapy and risk of stroke.
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Given the widely variant survival characteristics of women with advanced ovarian cancer, discrete quantifiable differences in tumor biology must exist. Heretofore, accurate characterization has been elusive.
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The rationale for this study is interesting. As the trial investigators point out, oxidative injury has been implicated as a key mechanism, leading to atherosclerotic cardiovascular disease and cancer.
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Is Holding NSAIDs Prior to Surgery Rational?; Low-Dose Aspirin: Men vs Women; FDA Actions