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The lead paper in the November issue of Obstetrics and Gynecology should stimulate lively discussion regarding the counseling of patients of advanced maternal age (AMA), and, if taken at face value, could impact the field of prenatal diagnosis, in general.
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The resection of tumor nodules (or cytoreduction) before primary chemotherapy has been linked closely with survival in patients with advanced epithelial ovarian cancer. Chi and colleagues set out to evaluate the merits of cytoreduction completeness in a homogeneous cohort of ovarian cancer patients with bulky metastatic disease.
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Kahlenborn and colleagues performed a meta-analysis of case-control studies published after 1979 that focused on the use of oral contraceptives and the risk of premenopausal breast cancer.
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Drug Labels A Prescription for Misunderstanding?; Osteonecrosis of the Jaw New Side-Effect to Bisphosphate Use; Beta-Blockers and Depression Unlinked?; FDA Actions
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Lacey and colleagues from the National Cancer Institute reported the results of postmenopausal hormone exposure in a cohort study with 214 cases of ovarian cancer.1 The over-all cohort of 97,368 women constituted the NIH-AARP Diet and Health Study.
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Blumenthal and colleagues point out in the introduction that psychological factors are recognized to play a significant and independent role in the development of ischemic heart disease and its complications, but it is not clear if psychological or behavioral interventions will reverse established cardiac conditions. They undertook the present study to test the hypothesis that stress reduction would lead to better cardiovascular health in individuals with established ischemic heart disease.
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Odvina and colleagues report 9 patients (8 women and 1 man) who sustained spontaneous, atraumatic, nonspinal fractures while on alendronate treatment. One patient also had a lumbar spinal fracture, but almost all of the fractures occurred in skeletal sites rich in cortical bone. In addition, 6 of the 9 patients displayed either delayed or absent fracture healing.