OB/GYN Clinical Alert
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Mothers, Babies, and HPV: Thanks for Not Sharing!
Nearly half of pregnant women in a Canadian study had vaginal swabs positive for human papillomavirus (HPV) deoxyribonucleic acid (DNA). Only about one-fourth of placentas and newborns produced by those HPV-positive women carried detectable HPV DNA, and all HPV-positive babies had cleared their positivity by 6 months of age.
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Cabergoline: An Effective Intervention for Unwanted Lactation After Second Trimester Uterine Evacuation
In this double-blind, randomized controlled trial among 73 patients between 18 and 28 weeks’ gestation undergoing dilation and evacuation or induction of labor for abortion or fetal demise, a one-time dose of 1 mg of cabergoline compared to placebo reduced post-delivery lactation-related breast symptoms in the treatment arm (27.8% vs. 97.0%; relative risk, 0.05; 95% confidence interval, 0.01-0.33).
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Effectiveness and Safety of Low-Dose Aspirin to Prevent Preterm Preeclampsia
An aspirin dosage of 150 mg to 162 mg per day, when started in the first trimester of pregnancy, was linked to a decreased risk of preterm preeclampsia compared to an aspirin dosage of 75 mg to 81 mg per day.
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Is It Safe to Skip the Pelvic Examination Before Gender-Affirming Hysterectomy and Vaginectomy?
A retrospective chart review of individuals undergoing gender-affirming hysterectomy, vaginectomy, or both found no difference in 30-day perioperative outcomes between those who received a preoperative internal pelvic examination and those who did not. These findings indicate that omitting such potentially triggering exams may be safe.
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Preconception Hepatitis B and Congenital Heart Disease
A new study suggests that both women and men who have had hepatitis B infection prior to conceiving offspring are more likely to give birth to children with congenital heart disease.
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Maternal, Fetal, and Infant Implications of a Positive Syphilis Screening During Pregnancy
Although syphilis screening during pregnancy is effective in identifying maternal syphilis, it is not without consequences. False-positive syphilis testing can result in unwarranted antibiotic therapy; re-screening based on risk is not always consistent, and among pregnant women who truly test positive to syphilis, treatment is not always optimized to prevent congenital syphilis.
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Barriers to Urogynecologic Care
There is a paucity of literature on barriers to urogynecologic care in racial/ethnic minorities. Continued evaluation is needed to better understand the unique barriers to urogynecologic care in these populations.
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Ovarian Torsion: What Is the Best Surgical Management Strategy?
In this national retrospective cohort study from 2008 to 2020, there were 1,791 surgeries for adnexal torsion, with 30.3% involving ovarian conservation and the remainder undergoing oophorectomy. The proportion of oophorectomies compared to ovarian conservation decreased slightly over the study period (average decrease, -1.6% per year; 95% confidence interval, -3.0%- to -0.22%).
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Oral Medication to Treat ‘Hot Flashes’ Could Be Available Soon
The FDA has approved the first neurokinin 3 receptor antagonist to alleviate symptoms associated with moderate to severe vasomotor symptoms caused by menopause.
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Identifying and Testing BRCA Gene Variant Carriers Meeting NCCN Criteria
A large percentage of patients who meet criteria for breast cancer gene (BRCA) testing based on family history do not have it completed until after a personal cancer diagnosis, thus missing the opportunity for risk-reducing strategies.