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Cromer et al performed a 24-month observational, prospective cohort study of adolescents in the Midwest using depot medroxyprogesterone acetate (DMPA), oral contraceptives (OCs), or nothing. DEXA scans were performed at baseline and 6-month intervals.
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A 3-year randomized, double-blind clinical trial in 206 sites throughout the world compared bazedoxifene (20 mg or 40 mg) and raloxifene (60 mg) with placebo.
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A randomized, double-blind, placebo-controlled trial comparing Ginkgo biloba with placebo for the prevention of dementia enrolled 3069 elderly individuals (older than age 75) in 5 academic centers in the United States.
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In this issue: Drug combinations for hypertension; tenecteplase for out-of-hospital cardiac arrest; CAM most commonly used for back, neck, and arthritis pain; FDA Actions.
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Polycystic ovarian syndrome patients with normospermic partners undergoing ovulation induction with letrozole had a higher live birth rate and no increase in adverse outcomes than women who received clomiphene citrate.
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According to this pharmacokinetic study, the cyclic use of 20 mcg ethinyl estradiol oral contraceptives is problematic for obese women. Ovarian activity was better suppressed with continuous use (omitting the hormone-free interval) of the same dose oral contraceptive or increasing to a higher dose 30 mcg ethinyl estradiol oral contraceptive
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A large prospective cohort study of perineal talc use demonstrated no increased risk of ovarian cancer overall or within any histological subtype. In addition, no association with talc application method was observed.
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A recent study in patients with fibroids has correlated the size, location, and number of fibroids with the rate of preterm birth, postpartum hemorrhage, need for cesarean section, and fetal size findings that can be useful in counseling patients with fibroids.
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