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Preclinical data recently demonstrated the extreme sensitivity of BRCA-deficient cells to inhibition of the single-strand repair enzyme poly(ADP-ribose) polymerase (PARP).
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In this issue: Clopidogrel and proton pump inhibitors; adverse events with tamsulosin after cataract surgery; new guidelines for persistent pain in the elderly; and FDA Actions.
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According to results of a Gallup Organization survey released during the American College of Obstetricians and Gynecologists (ACOG) 57th Annual Clinical meeting in Chicago, women are delaying important preventive carein the form of pregnancy and annual check-upsas a result of the economy.
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Successful screening for ovarian cancer, the gynecologic malignancy with the highest case to fatality ratio, has been elusive due to the low prevalence of disease in the general population and the high cost for modalities needed to produce testing specificity acceptable for routine use. The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) was designed to definitively assess the effect of ovarian cancer screening on mortality, as well as, to comprehensively address the cost, acceptance, physical and psychosocial morbidity, and performance characteristics of multimodal screening (MMS) and ultrasound-based screening (USS).
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The medical community has been well aware of the importance of adequate intake of folic acid in the prevention of neural tube defects (NTDs). However, less attention has been given to its role in the development of the fetal heart.
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I hate statistics. I don't understand statistics. Statistics are so confusing. How many times have these statements (or something like them) crossed your lips? I know that I certainly feel that way sometimes.
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The Mayo Clinic Cohort Study of Oophorectomy and Aging included 1274 premenopausal women with unilateral oophorectomy (followed for a median of 29.5 years) and 1091 premenopausal women with bilateral oophorectomy (followed for a median of 25 years) who had surgery from 1950 through 1987, compared with 2383 matched women from the same population of women who had not undergone oophorectomy.
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n this issue: NSAIDs in the elderly; managing GI and CVD risk with NSAIDs; low-dose naltrexone and fibromyalgia; treating glucocorticoid-induced bone loss; FDA Actions.