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Bevacizumab is a fully humanized, monoclonal antibody targeting the proangiogenic factor, vascular endothelial growth factor or VEGF.
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Pockaj and colleagues from the Mayo Clinic reported the results of a double-blind, randomized, cross-over clinical trial to study the efficacy of black cohosh for the treatment of menopausal hot flushes.
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Two longitudinal cohort studies assessed the onset of depressive symptoms and disorders during the perimenopausal transition. The Penn Ovarian Aging Study followed over 8 years 436 women with no history of depression and correlated hormonal changes with the new onset of depressed mood.
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After using steroids for many years, it is now clear from randomized trials that betamethasone/dexamethasone can stimulate pulmonic maturity in preterm fetuses.
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The STAR Trial (Tamoxifen and Raloxifene); FDA Actions
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Twenty-three patients are reported with osteonecrosis of the mandible or maxilla associated with bisphosphonate treatment.
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In this New Zealand investigation, 257 premenopausal women undergoing hysterectomy were prospectively compared to 259 cohorts who did not have a hysterectomy.
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One of the most recognized risk factors for the development of endometrial cancer is obesity. However, recent studies have suggested that this factor alone cannot fully account for all the risk associated with obesity.
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In this case-control study, the authors matched 235 graduates of 3 medical schools who were disciplined by their respective medical boards between 1990 and 2003 with 469 control physicians who were matched based on graduation year and medical school.