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Antiaging Supplements Proven Ineffective; The Three Most Common Culprits of ADE; New Guidelines for Lyme Disease Prevention; FDA Actions
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Bonny and colleagues report the effect of depot medroxyprogesterone on weight changes in obese and nonobese adolescent girls. This was a prospective study of 450 adolescents, aged 12 to 18 years.
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Clarkson and colleagues report the results of a lower-dose estrogen trial in a monkey model of coronary atherosclerosis. The animals were fed an atherogenic diet for 10 months, calculated to induce atherosclerosis comparable to that observed in early postmenopausal women.
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In November the authors of the now famous FASTER trial, which was initially focused on the use of nuchal translucency (NT) in the first trimester, published one of many spin-off reports.
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The Womens Health Initiative (WHI) conducted a randomized trial of Calcium and Vitamin D supplementation.1 The 36,282 postmenopausal women were part of the WHI clinical trials involving postmenopausal hormone therapy or dietary modification. The average follow-up was 7 years; 37% of the women were age 50 to 59, 45.5% were 60 to 59, and 17.5% were 70 to 79.
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Treatment of Benign Prostatic Hyperplasia; Treatment of Osteoarthritis of the Knee; Refractory Asthma and TNFConnection?; FDA Actions
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The association between exogenous estrogen use and endometrial cancer development has been well documented. Nonetheless, the hazard of estrogen replacement therapy in women with a personal history of endometrial cancer has not been well studied and, despite anecdotal evidence of its safety, is largely discouraged among clinicians.
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Jick and colleagues, epidemiologists at Boston University School of Medicine, performed a case-control study of nonfatal venous thrombosis using information derived from a very large database that records prescriptions and diagnoses longitudinally in managed health care plans.
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Optimal surgical cytoreduction is a recognized staple of initial advanced ovarian cancer care. However, within the spectrum of patients who undergo this surgery are those in whom complete resection is either impossible or unwarranted in the face of certain unacceptable morbidity.