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The Osteoporosis Prevention and Arterial Effects of tiboLone (OPAL) study was a 3-year, randomized, double-blind trial in 6 US centers and 5 European centers, treating 866 postmenopausal women with either 2.5 mg tiboLone daily, 0.625/2.5 mg daily of conjugated estrogens/medroxyprogesterone acetate, or placebo.
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Advanced stage endometrial cancer represents a significant therapeutic challenge as it encompasses patients with a diverse spectrum of disease and recurrence risk. Currently, most patients are treated following primary surgical extirpation with a modality either directed at tumor residua or to a high-risk locale of recurrence. Either or both radiation therapy and chemotherapy have been used.
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In the January issue of the American Journal of Obstetrics and Gynecology an article from Japan appeared that will shed new light on the practice of using cerclage in patients with short cervices. Over a 5-year period 16,508 had transvaginal ultrasound evaluations between 20-24 weeks.
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The authors sought to determine the relationship between psychiatric and sexual status of premenopausal women with fibromyalgia compared to a control group of healthy women.
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A medline search was conducted for comparisons of vaginal hysterectomy in patients with/without previous cesarean delivery. As might be anticipated, the studies were heterogeneous. For example, in one study, some cases had laparoscopic assistance.
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In the vast majority of hospitals magnesium sulfate has been the drug of choice to stop labor in patients presenting with preterm contractions.
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This study was made possible by the mayo Clinic Cohort Study of Oophorectomy and Aging, the main aim of which is to detect new cases of age-related diseases, especially Parkinson's disease and dementia. This report focused on the mortality outcomes.
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The therapeutic role of lymphadenectomy in patients with endometrial cancer is controversial and challenging to study given the relative infrequency of metastatic disease and the generally good prognosis of newly diagnosed patients. Nevertheless, prior work in limited sized cohorts has suggested that the number of nodes resected may be prognostic and informative in planning subsequent adjuvant treatment.
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The purported advantages of the tension-free vaginal tape obturator (TVT-O) procedure include avoidance of bowel damage, reduction in risk of bladder and major vessel damage, and elimination of the need for routine cystoscopic evaluation during insertion.
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