OB/GYN Clinical Alert
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OnabotulinumtoxinA and the Bladder
ABSTRACT & COMMENTARY: Healthcare providers should thoroughly counsel patients on the risks associated with onabotulinumtoxinA toxin injections.
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Farewell and Welcome
Dr. Robert Coleman, a member of the editorial board of OB/GYN Clinical Alert since 2004, has been elected as the next President of the Society of Gynecologic Oncologists.
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Postoperative Delirium in Older Adults
The elderly operative patient has very different and specific needs compared to a younger woman. In addition to a higher risk of medical comorbidities, elderly women are affected by cognitive impairment, depression, gait, and balance disturbances.
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NIPT and Invasive Procedures
A single prenatal testing center with a large volume of patients has experienced a dramatic drop in the rate of chorionic villus sampling and amniocentesis after the introduction of noninvasive prenatal testing.
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Hormonal Contraception and Glioma: Is There Reason for Concern?
A large case-control study using the Danish National database found a slight increase in the risk of glioma in ever-users of hormonal contraception, which increased with duration of use. Users of progestin-only methods were at higher risk. However, these findings should not influence clinical practice or perception of contraceptive safety.
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Finding New Clinical Activity in Endometrial Cancer from Optimizing Molecular Pathways
Everolimus, combined with letrozole, produced unexpected clinical activity in a cohort of previously treated recurrent endometrial cancer patients.
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Endometrial Protection: Which Progestogen Is Best?
After a lost decade, increasing numbers of women and providers are recognizing the benefits of postmenopausal hormonal therapy. For women with an intact uterus, endometrial protection is required when systemic estrogen therapy is used. Since activity at the glucocorticoid and androgen receptor may lead to adverse health effects in some women, use of pure progesterone receptor agonists may offer advantages. However, the use of natural progesterone is problematic due to low potency and poor bioavailability with oral dosing. Local therapy with the levonorgestrel intrauterine device (off-label) may be an excellent choice for many women. -
Delayed Cord Clamping
Although a recent study has failed to show major benefit from delayed umbilical cord clamping, others have suggested neonates having delayed cord clamping have less need for transfusion, higher hematocrits, less neonatal morbidity, and diminished risk of intraventricular hemorrhage. -
Intercourse at the Time of Implantation Confers Lower Chance of Conception
Couples attempting natural conception were found to have a lower chance of success per cycle when intercourse took place at or around the time of implantation. -
Weight Gain with Contraception
In this prospective cohort study, perceived weight gain was found to be an adequate predictor of actual weight gain. Depot medroxyprogesterone acetate and the contraceptive implant were associated with more weight gain than the copper IUD.