OB/GYN Clinical Alert
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Perimenopausal Depression
OB/GYNs strive to screen women for perinatal depression both in pregnancy and postpartum. Although depression frequently affects reproductive-age women, it is common in women throughout the lifespan. This article discusses depression in perimenopausal women.
Brexanolone for Postpartum Depression: Promising, but Will It Deliver?
In two double-blind, randomized, placebo-controlled, Phase III trials of brexanolone, a new medicine for postpartum depression, researchers found a significant reduction in symptoms at 60 hours of infusion compared to placebo.
Pregnancy Temporarily Increases Breast Cancer Risk: Parallels to Hormonal Contraception?
In a pooled analysis of prospective studies, researchers found an increased risk of breast cancer among parous women that persists for more than 20 years after childbirth. Breastfeeding did not modify this pattern.
Low-Dose Aspirin and Preterm Birth
SYNOPSIS: A reanalysis of an earlier randomized clinical trial to assess the ability of low-dose aspirin to prevent preeclampsia has shown that the drug diminishes the risk of spontaneously delivering prior to 34 weeks by about half.
Does Treatment of Bacterial Vaginosis Prevent Spontaneous Preterm Birth?
In this randomized, controlled trial from France, screening for and treatment of bacterial vaginosis in pregnant women at low risk for preterm birth with oral clindamycin or placebo did not reduce the rate of spontaneous preterm birth between 16 and 36 weeks.
Paternal Age Is Important for Perinatal Outcomes
Fathering infants at or after age 45 years is associated with negative effects on both the mothers and the resulting offspring.
Acupuncture as Adjunct Therapy for Infertility in Polycystic Ovary Syndrome
Acupuncture as an adjunctive therapy for treating infertility in Chinese women with polycystic ovary syndrome receiving clomiphene citrate or placebo offered no benefit over sham acupuncture.
Initial Management of Patients With Medication-Overuse Headache
As part of a randomized treatment trial for medication-overuse headache, a simple protocol that provided early advice on stopping excessive medications was effective in one-third of patients, even before any prophylactic medications were started.
Hormone Therapy and Mortality: No Overall Effect?
An evaluation of outcomes of users and nonusers of postmenopausal hormonal therapy followed longitudinally in the Danish database showed no overall difference in mortality.
Should the Copper IUD Be Offered to Women With Heavy Menstrual Bleeding?
In this secondary analysis of the Contraceptive CHOICE Project, there was no difference in copper intrauterine device continuation rates at one year between 165 women who reported heavy menstrual bleeding at baseline and 753 women who did not.