OB/GYN Clinical Alert
RSSArticles
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Polycystic Ovary Syndrome: Etiology Likely Heterogeneous?
Rare noncoding variants of the gene DENND1A, previously shown to play a key role in androgen biosynthesis in human ovarian theca cells, are significantly associated with familial polycystic ovary syndrome.
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Maternal Drug-Related Death and Suicide: Leading Causes of Postpartum Death in California
In a recent study, investigators found that drug-related death and suicide were leading causes of postpartum death in California.
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Vaginal Bowel Control System for Nonsurgical Treatment of Fecal Incontinence
The vaginal bowel control device provides a safe, effective, and durable treatment option for women with fecal incontinence.
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Estrogens Used in Hormonal Therapy
To practice as a consultant in reproductive medicine, clinicians require a strong background in hormonal therapy. In this feature, we will review the role of steroidal estrogens used in contraceptive and hormone therapy.
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Perioperative Antibiotics in Gynecologic Surgery: The Case for Myomectomy
The authors of a retrospective cohort study suggest that perioperative antibiotics reduce the risk of surgical site infection in women undergoing myomectomy.
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Does Hormone Therapy Increase the Risk of Alzheimer’s Disease?
A large Finnish case-control study suggests that postmenopausal hormone therapy results in a 9-17% increase in the risk of Alzheimer’s disease. However, the small effect size, and likely confounding of use effect, does not provide strong evidence for a causal relationship.
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Multimodal Stepwise Post-Cesarean Pain Control Reduces Opioid Use
These investigators found that the routine use of acetaminophen alone rather than a combination acetaminophen-opioid significantly reduced overall and daily opioid use. In addition, there was no worse effect on overall pain score or length of stay.
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Thank You, John Hobbins; Welcome Camille Hoffman
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Should All Pregnant Women Be Screened for Hepatitis C?
In this cost-effectiveness analysis using Markov modeling, investigators found that universal antenatal screening for hepatitis C was cost-effective, with a mean incremental cost-effectiveness ratio of approximately $3,000 per quality-adjusted life years gained compared to risk-based screening.
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Staged Preeclampsia Screening in Early Pregnancy
The use of 150 mg of daily aspirin from 11 to 14 weeks through 36 weeks of gestation reduces the rate of early preeclampsia (PE) in approximately 90% of at-risk pregnancies. In addition, aspirin also provides the benefit of reducing the risk of PE < 37 weeks by about 60% and the length of NICU stay by about 70%, primarily by reducing the number of neonates delivered before 32 weeks. What constitutes a high-risk patient and what quantifies patient-specific risks before PE develops remain to be answered.