OB/GYN Clinical Alert
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Fezolinetant Shows Positive Response in Vasomotor Symptoms Associated with Menopause
A phase 2b trial using seven dosing regimens of a novel neurokinin-3 receptor antagonist, fezolinetant, shows statistically significant improvement in vasomotor symptoms vs. placebo in postmenopausal women.
Does a Standardized Recovery Bundle After Cesarean Delivery Decrease Length of Stay?
Implementation of an enhanced recovery bundle after cesarean delivery reflected diverse positive outcomes. However, length of stay was reduced only by an average of two hours.
Is RhoGAM Needed for Rh-Negative Women Experiencing First-Trimester Pregnancy Loss or Induced Abortion?
In this prospective cohort pilot study, the authors validated a flow cytometry protocol for detecting fetal red blood cells and determined that fetal red blood cell exposure in first-trimester uterine aspiration was well below the calculated threshold for maternal Rh sensitization.
Restricting Access to Abortion Increases Complications
Restrictive abortion laws increase the chance that a woman will self-manage her abortion, a practice associated with an increased risk of complications.
Should Metronidazole Be Added Routinely to Treatment Regimens for PID?
In this randomized, double-blind, controlled trial, routine treatment with metronidazole compared to placebo in addition to doxycycline and ceftriaxone reduced the presence of endometrial anaerobes, Mycoplasma genitalium, and pelvic tenderness at 30 days post-treatment. However, clinical improvement at three days post-treatment was no different between the two groups.
COVID-19 and Pregnancy: What Obstetricians Need to Know
While data remain limited on this particular coronavirus, extrapolation from other viruses (severe acute respiratory syndrome and Middle East respiratory syndrome), and best clinical observations and expert recommendations have led to current guidelines in care.
Diet Modification in Older Women with Fecal Incontinence
Older women with fecal incontinence manage their symptoms with dietary modification.
The Global COVID-19 Pandemic Was Predicted and Ignored
The human population explosion, international travel and migration, urbanization, and environmental exploitation set the stage for pandemics, and the trend likely will continue and intensify.
Young Cancer Survivors at Increased Risk of Subsequent Endocrine Disease
A large Danish-based population cohort study documents that survivors of cancers arising in adolescence and young adulthood are at increased risk of subsequently developing a variety of endocrine disorders.
Impact of Weight Loss on Lower Urinary Symptoms and Urinary Incontinence in Overweight and Obese Women
Weight loss interventions are associated with improvements in urinary incontinence in overweight and obese women at 1 to 2.9 years.