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Long-term treatment (up to 5 years) with soy phytoestrogens was associated with an increased occurrence of endometrial hyperplasia. These findings call into question the long-term safety of phytoestrogens with regard to the endometrium.
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A majority of patients scheduled for endometrial ablation or a levonorgestrel-releasing IUD were willing to accept a 50% likelihood of treatment failure to avoid hysterectomy.
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Good outcomes with vasa previa depend primarily on prenatal diagnosis and cesarean delivery at 35 weeks of gestation or earlier should rupture of membranes, labor, or significant bleeding occur.
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These data support the hypothesis that favorable survival that is associated with optimal debulking of advanced ovarian cancers is due to, at least in part, the underlying biologic characteristics of these cancers.
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The canceled estrogen-progestin arm of the Womens Health Initiative reported an increase in ovarian cancer that was not statistically significant, prompting the authors to say: The possibility of an increased risk of ovarian cancer incidence and mortality remains worrisome and needs confirmation.
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Abdominal myomectomy might improve reproductive outcome in cases of intramural or subserosal fibroids especially if the patient is less than 30 years of age and the myoma is single.
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It is hard to believe, but whom, how, and when to screen for thyroid disease is a highly controversial topic. The controversy is fueled by uncertainty about which populations are at risk, short-term cost vs benefit considerations, lack of consensus about when to initiate treatment, whether to use a mix of thyroxine and thyronine, and debate about the long-term risks of treating vs not treating asymptomatic individuals.
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Hypothyroidism and Pregnancy; Anti-Depressants and the Risk of Suicide; FDA Actions; Brief Notes.
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The womens health initiative reported their results on cognition and dementia combining the canceled estrogen-only arm with the canceled estrogen-progestin arm of the randomized trial; the data are derived from an ancillary study of the trial entitled The Womens Health Initiative Memory Study (WHIMS).