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Warfarin Effectively Prevents Venous Thromboembolism; Vitamin D Reduces Osteoporotic Fractures; Adefovir Effective for Hepatitis B Treatment; Ibuprofen/Aspirin Study Revisited; ACE Inhibitors Favored in Cardiovascular Care; Digoxin Dosing and Heart Failure
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Synopsis: Postpartum fever after cesarean delivery is associated with an increased risk of uterine rupture during a subsequent trial of labor.
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Synopsis: Acute oral administration of 50 mg and 100 mg of androstenedione to postmenopausal women increases serum testosterone and estrone but not estradiol.
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Synopsis: The clinical value of single-agent trastuzumab in recurrent ovarian cancer is limited by the low frequency of HER2 overexpression and low rate of objective response among patients with HER2 overexpression.
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Smallpox Vaccination Guidelines Published by CDC; Nurses: Delay Vaccination Program; Viagra Effective for Depression Treatment; Finisteride/Doxazosin no Better than Placebo for Urinary Obstruction; Serevent Receives Dear Doctor Letter
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There are 2 important potential uses for the measurement of testosterone levels: 1) to monitor the dosage of testosterone supplementation; and 2) to diagnose hyperandrogenism, whatever the cause. Unfortunately, the measurement of testosterone is particularly difficult in women because of the low circulating levels.
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The potassium sensitivity test (PST) was administered to 244 patients with pelvic pain and 47 control patients by enrolling gynecologists at 4 separate facilities. Previous work by these physicians had shown that the test appears to identify the presence of interstitial cystitis (IC) by detecting abnormal permeability of the bladder epithelium.
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The FDA has mandated a Black Box warning for all estrogen and estrogen/progestin products for use by postmenopausal women. The new warnings are based on analysis of data from the Womens Health Initiative (WHI) study that was published July 2002.
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Ventilation/perfusion scanning appears to be safe and effective, at least in ruling out significant clinical pulmonary embolism in pregnant patients. However, prospective studies over longer time periods should be undertaken to validate these conclusions.