-
The association between oral contraceptive use and ovarian or breast cancer in BRCA1 or BRCA2 mutation carriers are qualitatively similar to associations reported in the general population. Oral contraceptive pill use is inversely associated with ovarian cancer risk. However, it is also associated with a modest, but not statistically significant, increased risk for breast cancer. The analysis was unable to provide conclusive recommendations as to their use as preventive measures given these and other unmeasured risks. However, oral contraceptive pills appear safe for contraception in this population.
-
Synopsis: The Nurses Health Study reports an increased incidence of breast cancer with daily alcohol consumption, hormone therapy, and an additive effect with greater drinking.
-
-
After years of legal wrangling, the FDA has approved loratadine (Claritin, Schering-Plough) as an over-the-counter (OTC) product for the treatment of seasonal rhinitis.
-
The Womens Angiographic Vitamin and Estrogen (WAVE) Trial was a randomized, controlled secondary prevention study. This study enrolled 423 postmenopausal women with coronary atherosclerosis already established at baseline by angiography.
-
Synopsis: The hazard ratio for death from breast cancer for patients with high total cyclin E levels as compared with those with low total cyclin E levels was 13.3 to about 8 times as high as the hazard ratios associated with other independent clinical and pathological risk factors, including axillary node status.
-
Synopsis: Involvement of a gynecologic oncologist at the time of primary surgery for endometrial cancer was associated with comparable outcomes in both the university and community hospital setting.
-
Synopsis: Sertraline was significantly more effective than placebo when taken during the luteal phase for PMDD.
-
Synopsis: Women with pregestational diabetes or gestational diabetes plus fasting hyperglycemia have a 3- to 4-fold increased risk of infant malformations, whereas women with mild gestational diabetes have malformation rates no different than the general nondiabetic obstetric population.
-
Oz and colleagues recently re-explored the possible etiology of the oligohydramnios sometimes seen in post-term pregnancy.
