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The results of the PEARL I and PEARL II studies were published recently in the same issue of the New England Journal of Medicine. Both were well-designed, randomized, controlled, double-blinded studies that assessed the safety and efficacy of ulipristal acetate (UPA) for the treatment of symptomatic uterine fibroids.
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In this issue: Statins and diabetes risk; new treatment guideline for diabetes; new pertussis vaccine recommendation; antibiotics and rhinosinusitis; fluoroquinolones and cystitis; and FDA actions.
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It has been long recognized that thrombocytosis (defined as a platelet count > 450,000/mm3) frequently accompanies the diagnosis of advanced cancer and has been associated with poor outcomes.
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The authors conducted a double-blind, randomized, controlled trial to determine whether the postoperative use of a levonorgestrel intrauterine system (LNG-IUS) was an effective treatment for chronic pelvic pain in women with endometriosis.
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Managing labor is an art, while the actual delivery process requires the addition of skill and experience. Yet, the decision of which route of delivery to employ may have the greatest impact on outcome. A recent article deals with neonatal morbidity, including an important contributor, intracranial injury, and its association with various forms of operative delivery.
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In this study, 4957 women aged 67 and older were followed prospectively for up to 15 years. Statistical models were used to calculate the bone mineral density (BMD) testing interval for women with normal BMD and those with mild, moderate, or advanced osteopenia.
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Women who carry a deleterious germline mutation in BRCA1 or BRCA2 have a substantially higher lifetime risk of developing ovarian cancer.
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In this retrospective study of young women performed in New Zealand between 2005 and 2009, 57% of 452 patients with biopsy-proven cervical intraepithelial neoplasia (CIN) 2 were treated immediately whereas 157 (35%) met the criteria for conservative management.
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A number of previous reviews in OB/GYN Clinical Alert, including a Special Feature, have been devoted to preterm birth (PTB), a problem that has been on the rise in the United States despite significant efforts to curb it.
