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Inhibition of thromboxane A2 synthesis by aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) underlies the risk of bleeding complications associated with their use. Aspirin use is associated with a reduced risk of thrombotic events and possibly an increased risk for intracerebral hemorrhage (ICH).
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Consider this all-too-familiar scenario. Patient X awakens from otherwise uneventful abdominal surgery and complains of ulnar nerve distribution weakness or tingling, or both. Ulnar neuropathy at the elbow (UNE) is documented, litigation ensues, and large sums of money exchange hands. Who is guilty and of what?
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There is little doubt that cerebrovascular disease is a major contributor to cognitive decline in the elderly. Recurrent symptomatic strokes affecting cortical or subcortical function inevitably result in a stepwise burden of accumulating damage and disability.
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Confavreux and colleagues studied 1844 multiple sclerosis (MS) patients enrolled in a large European database up until 1997. Clinical variables were identified early in the course of the disease, and their continued prognostic significance was determined after the first stages of irreversible neurological disability.
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Currently, there are no medications specifically approved in the United States for treatment of the advanced stages of Alzheimers disease (AD). Results of the first US large-scale, prospective, double-blind study of memantine in the treatment of moderate-to-severe AD indicate that memantine-treated advanced AD patients fare better than those who received placebo, with no significant treatment-related side effects.
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Detection of Alzheimers Disease and Dementia in the Preclinical Phase; Shoe Design and Plantar Pressures in Neuropathic Feet; Serum Thyroid Stimulating Hormone in Assessment of Severity of Tissue Hypothyroidism in Patients with Overt Primary Thyroid Failure.
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A high intake of nondairy protein may accelerate renal function decline in women with mild renal insufficiency.
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Adding continuous positive airway pressure (CPAP) to medical therapy in patients who have obstructive sleep apnea and congestive heart failure both improves systolic function and lowers blood pressure.
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Keeping the INR in the range of 1.5 to 2.0 is safe and effective.
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The FDA recently approved a new class of antiretroviral drug for treatment of patients with resistant HIV infections.
