Neurology
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Trends in Supplemental Vitamin D Intake
Researchers investigated the trends in daily supplemental vitamin D intake of ≥ 1,000 IU and ≥ 4,000 IU and found increasing use of vitamin D supplementation.
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Thinking Outside of the ‘Alpha-Synuclein Box’: A Critical Role of Tau in Lewy Body Disorders
Neocortical tau pathology was associated with worse antemortem cognition in this large study of Parkinson’s disease dementia and dementia with Lewy bodies. Regional brain variations correlated with specific cognitive domains.
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Predicting the Risk of Mild Cognitive Impairment Using Imaging Biomarkers
In this population-based study, researchers used imaging biomarkers of amyloid and neuronal injury to estimate an absolute risk of mild cognitive impairment in the elderly.
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Amyloid-ß Pathology Induced by Contaminated Cadaver-Derived Growth Hormone
Cadaveric pituitary-derived growth hormone that previously was known to transmit Creutzfeldt-Jakob disease (CJD) also contains ß-amyloid. Growth hormone vials from cases associated with amyloid plaques in CJD patients cause amyloid plaque formation and cerebral amyloid angiopathy when injected intracranially into mice.
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Rituximab for CIDP Associated With Systemic Immune Disorders
Rituximab has been used “off label” for the treatment of primary chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with variable reports of success. These authors reported a high rate of response in patients who developed CIDP in the setting of other systemic immune-mediated disorders.
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Continuous EEG Monitoring in Critically Ill Patients Is Associated With Reduced Hospital Mortality
In this retrospective cross-sectional study involving more than 7 million critically ill adult patients from the National Inpatient Sample database, researchers showed that the use of continuous electroencephalography is associated with lower in-hospital mortality.
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Prucalopride Tablets (Motegrity)
Prucalopride is indicated for the treatment of chronic idiopathic constipation in adults.
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Should Acute Appendicitis Be Managed Without Appendectomy?
A retrospective cohort study that used national insurance claims data revealed patients with acute appendicitis who were treated nonsurgically experienced higher rates of complications and higher overall care costs.
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Alcohol Use: No Safe Level
A systematic analysis of data from the Global Burden of Disease Study 2016 on alcohol-linked disorders and patterns of alcohol use over 25 years worldwide found there is no safe level of alcohol consumption.
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Helicobacter pylori: A Mini Primer
Although the prevalence of Helicobacter pylori seems to be decreasing in the United States, at least in higher socioeconomic strata, it remains a problem for lower-income groups, travelers to developing countries, and the rest of the world.