Neurology
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EEG Reactivity for Prediction of Neurological Outcomes After Cardiac Arrest
This prospective, multicenter cohort study aimed to determine the utility of electroencephalographic reactivity (EEG-R) testing in neurological prognostication of comatose patients after cardiac arrest. The authors found that EEG-R testing, by itself, is not sufficiently reliable to predict neurological outcomes after cardiac arrest.
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Statin Use Moderately Reduces Dementia Risk After Concussions in Older Individuals
In a large population study, concussion in older adults resulted in significantly higher risk for dementia that was modestly reduced among those taking a statin.
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Essential Tremor and Dystonic Tremor: Similar Appearance but Different Cerebral Networks
Using MRI BOLD and seed-based functional connectivity, during a grip-force task, network-level connectivity was shown to be highly distinct between two otherwise phenotypically overlapping tremor types — dystonic tremor and essential tremor.
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Clinical Features of Subdural Fluid Collections With Intracranial Hypotension
Clinical features of patients with spontaneous intracranial hypotension and bilateral subdural fluid collections differ from patients who sustained previous head trauma vs. those with cerebrospinal fluid leaks.
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Episodic Vertigo? Consider and Treat as Vestibular Migraine
Vertigo is a common and integral component of migraine and occurs with neuro-otologic abnormalities and psychiatric comorbidities. Treatment of episodic vertigo suspected to be due to vestibular migraine should mirror the multimodality treatment of migraine.
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Midazolam Nasal Spray (Nayzilam) CIV
Midazolam nasal spray should be prescribed to treat acute intermittent, stereotypic episodes of frequent seizure activity (acute repetitive seizures, seizure clusters) that are distinct from the patient’s usual seizure patterns.
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Physicians Cannot Agree on Who Benefits From ICU Care
The authors of a study randomizing U.S. critical care physicians to analyze hypothetical patient vignettes found that estimates of whether a patient would benefit from ICU care were widely dissimilar among those surveyed and influenced by factors unrelated to severity of illness.
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Does Hormone Therapy Increase the Risk of Alzheimer’s Disease?
The results of a large Finnish case-control study suggest that postmenopausal hormone therapy results in a 9-17% increase in the risk of Alzheimer’s disease. However, the small effect size, and likely confounding of use effect, does not provide strong evidence for a causal relationship.