Neurology
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Is It Safe to Stop Digoxin for Heart Failure?
In a large older patient heart failure with reduced ejection fraction hospitalizations database, the outcome of withdrawing digoxin vs. continuing digoxin was examined at 30 days and up to four years of follow-up. Withdrawing preadmission digoxin in hospital resulted in higher mortality at 30 days and more readmissions at six months, one year, and four years.
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The Role of Muscle MRI in the Diagnosis of Motor Neuron Diseases
The current study characterizes novel patterns of abnormalities on muscle magnetic resonance imaging (MRI) in patients with amyotrophic lateral sclerosis and spinobulbar muscular atrophy. Further, MRI changes correlate with disease severity.
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Stopping Cannabis Improves Cognitive Function in Patients With Multiple Sclerosis
The authors of a recent study evaluated the effect of discontinuing cannabis use in patients with multiple sclerosis. Stopping cannabis led to significant improvements in memory, processing speed, and executive function.
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Are Cyclic Vomiting Syndrome and Benign Paroxysmal Torticollis Precursors of Migraine?
Cyclic vomiting syndrome and benign paroxysmal torticollis in children frequently predict the subsequent onset of migraine later in life.
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Opening Potassium Channels — A Mechanism That Produces Migraine Headache May Offer New Treatment
The opening of ATP-sensitive potassium channels by levcromakalim triggered migraine headaches in all migraineurs. In healthy volunteers, levcromakalim induced milder headaches associated with long-lasting dilation of extracerebral arteries.
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Airplane-Triggered Headaches
Severe, unilateral headaches that occur during airplane travel, particularly during the landing, are most likely a variant of migraine headaches triggered by changes in cabin pressure.
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Semaglutide Tablets (Rybelsus)
Semaglutide is indicated as adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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After Ischemic Stroke Related to Atrial Fibrillation, Direct Oral Anticoagulants Are Superior to Vitamin K Antagonists
Researchers investigated the benefits and risks of early anticoagulation following acute ischemic stroke, and compared the effects of direct oral anticoagulants vs. vitamin K antagonists.
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Amyloid, Tau, Neurodegeneration Diagnostic Framework to Predict Memory Decline Before the Onset of Dementia
In a population-based longitudinal study of older individuals without dementia, the inclusion of imaging biomarkers for amyloid, tau, and neurodegeneration modestly improved the ability to predict memory decline compared to a model that only used clinical data and APOE genotype.
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Blood Pressure Targets in the Elderly
The authors of a large population study found that reducing blood pressure to < 140/90 mmHg is associated with increased mortality, and mortality was highest in those with previous cardiovascular events and age > 80 years.