Neurology
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Can You Interpret This Rhythm?
The long lead II rhythm strip in the figure was obtained from a middle-aged woman with syncope and hypotension. What can you say about the rhythm?
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Minocycline Topical Foam (Amzeeq)
Minocycline topical foam is indicated to treat inflammatory lesions of non-nodular moderate-to-severe acne vulgaris in patients ≥ 9 years of age.
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Anticoagulation Decisions in Atrial Fibrillation
Using the Delphi method of arriving at a consensus among clinicians concerning for which patients with atrial fibrillation should oral anticoagulants be recommended, the risk of stroke, the risk of hemorrhage, and patient-specific factors emerged. Many of these factors are not included in the guidelines and should be studied further.
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Treating Depression in Epilepsy: To Medicate or Not?
Epileptic patients with major depression were randomized to either cognitive behavioral therapy (CBT) or sertraline. Depression and related secondary health outcomes were analyzed in both groups. Sertraline and CBT were found to be equally efficacious with improvement in mood in more than half of patients.
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Optimism Could Increase Odds of ‘Exceptional Longevity’
An analysis of 10-year follow-up data from the Nurses’ Health Study and 30-year follow-up data from the Veteran Affairs Normative Aging Study revealed a significant association between baseline levels of higher optimism and longevity, even when data were adjusted for health behaviors and psychosocial factors.
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Does a Repeat Course of IVIg Help in Severe Guillain-Barré Syndrome?
In an open-label, non-randomized clinical trial using a second course of intravenous immunoglobulin (IVIg) to treat patients with Guillain-Barré syndrome, no benefit was observed. A single course of 2 g/kg of IVIg should be administered. No additional treatment is helpful.
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Stereotactic Radiosurgery for the Treatment of Cerebral Cavernous Malformations
In this comprehensive review of studies comparing treatments for cerebral cavernous malformations, there were no randomized or blinded outcome trials, and the most effective treatment remains uncertain.
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Submentalis REM Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy
Objective findings during polysomnography (REM sleep without atonia), as diagnosed with submentalis EMG recordings, may be a biomarker for synucleinopathies, such as Parkinson’s disease and multiple system atrophy.
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Fluctuating Cognition: An Often-Neglected Feature of Lewy Body Dementias
Clinical identification of fluctuating cognition is challenging. A better understanding of potential etiological mechanisms can allow for optimization of clinical assessment tools and targeted therapeutic approaches.
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Neuropathology and Dementia in Football Players With CTE
The authors of a cross-sectional study involving analysis of data from the ongoing Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) study found that dementia is likely a result of neuropathologic changes associated with repetitive head injury as well as non-head trauma-associated vascular pathologic changes in patients with chronic traumatic encephalopathy.