Neurology
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Inhaled Anesthetics Have Differential Experimental Effect on Memory Mechanisms
Isoflurane causes mitochondrial disruption and apoptosis in neuronal and hippocampal cells, and decreases memory consolidation in mice. Such effects are not seen with desflurane. This may impact selection of anesthetic agents for patients with Alzheimer's disease undergoing surgical procedures. -
Does a Lower Vitamin D Level Increase the Risk of Relapse in Inflammatory Spinal Cord Disease?
Based on a retrospective analysis of 77 patients with monophasic and recurrent inflammatory spinal cord disease, the authors report significantly lower vitamin D levels in patients with recurrent disease. -
Pharmacology Watch
Drug shortages; metformin and cancer prevention; migraine prevention guidelines; and FDA actions. -
Clinical Briefs in Primary Care Supplement
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Stroke Alert: A Review of Current Clinical Stroke Literature
Vorapaxar is a potent antiplatelet medication with a novel action that works by inhibiting thrombin activation of platelets through the protease-activated receptor PAR-1. -
Variable 'Faces' of Facioscapulohumeral Muscular Dystrophy
With the advent of specific genetic tests, atypical forms of facioscapulohumeral muscular dystrophy can be reliably diagnosed. -
Clinical and Radiological Features Associated with Rhombencephalosynapsis
This study presents a large group of new cases of rhombencephalosynapsis and carefully describes correlations to other associated morphological abnormalities as well as to outcomes. -
Optimal Weight Loss Diet to Reduce Cardiovascular Risk
The authors conclude that after weight loss, a low glycemic index and, to a lesser extent, low-protein diet may reduce inflammation associated with cardiovascular disease in overweight adults. -
FDA actions
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More to the avastin/breast cancer story?